Business Survivability in Potrero Hill, San Francisco
StreetSpring's 2026 analysis finds that the best business to open in Potrero Hill is a Chiropractor Office with a 82.9% chance of surviving at least 2 years across the neighborhood on average.
Quick Summary
- Survivability Score: the projected chance a business type lasts two or more years at a specific address
- Best business: a Chiropractor Office in Potrero Hill (82.9% average survival rate, 90.0% at best locations)
- Neighborhood rank: #19 of 107 neighborhoods in and around San Francisco
- Neighborhood average: 76.7% two-year survival across the business types ranked here
- Coverage: This ranking carries one row per business type and neighborhood. Its score is the projected chance of lasting two or more years, averaged across the price points StreetSpring scores separately in the tool (most types have 5). The 10 business types here are base types; the tool offers 500+ business types, counting each type at each of its price points.
- Rankings updated quarterly with latest market data
- Detailed methodology
Last reviewed: October 2026 by Robert Koons, Founder & CEO, StreetSpring
In this article:
- Summary
- Is Potrero Hill a good place to start a business?
- How to find the best location
- Best businesses to open
- How much money could a business make?
- What businesses should open next?
- Frequently Asked Questions
Summary
StreetSpring's 2026 analysis finds that the best business to open in Potrero Hill is a Chiropractor Office with a 82.9% chance of surviving at least 2 years across the neighborhood on average, with the best locations offering a 90.0% chance; next is an Eye Care Center with a 84.8% chance, followed by a Psychiatry or Psychology Practice with a 78.2% chance.
Is Potrero Hill a good place to start a business?
StreetSpring ranks Potrero Hill #19 of 107 neighborhoods in and around San Francisco, with an average Survivability Score of 76.7% across the business types ranked there.
- For the top-ranked business type, the best addresses in Potrero Hill score 7.1 points higher on the two-year chance than its average there.
- However, those same business types at the weakest addresses in Potrero Hill can score considerably below average. Even the most in-demand concept in Potrero Hill will struggle if it opens at the wrong address.
- The 94.5% employment rate in Potrero Hill supports consumer spending, while its 10.5% housing vacancy rate measures the share of homes and apartments standing empty: the model reads both as neighborhood characteristics.
Employment and housing vacancy figures sourced from the U.S. Census Bureau American Community Survey.
How can you find the best location to open a business in Potrero Hill?
StreetSpring's model evaluates every available address in Potrero Hill for your business type, ranking them by survivability so the best storefront is always identifiable. The map below highlights the highest-survivability address for a Chiropractor Office in Potrero Hill:
Based on StreetSpring's 2026 analysis of hundreds of location-specific factors, this area offers the highest projected survivability for a Chiropractor Office in Potrero Hill. Competition and spending patterns shift constantly; StreetSpring's live tool reflects the most current conditions for any specific address. Factors evaluated include competition at every distance band, consumer spending forecasts, mobility patterns, and market share projections.
Check if this location is still available →
What are the best businesses to open in Potrero Hill?
| # | Business type | Chance of lasting two or more years at a good address |
|---|---|---|
| 1 | Chiropractor Office | 89.6% |
| 2 | Eye Care Center | 89.2% |
| 3 | Mental Health Clinic | 87.4% |
| 4 | Acupuncture Clinic | 87.4% |
| 8 | Veterinary Clinic | 85.3% |
| 9 | Clothing Store | 85.0% |
| 10 | Convenience Store | 85.0% |
| 11 | International Grocery Store | 84.5% |
| 21 | Cosmetics Shop | 84.1% |
| 22 | Pizza Restaurant | 84.0% |
Ties at a good address: Mental Health Clinic and Acupuncture Clinic are tied; Clothing Store and Convenience Store are tied. A tie is a tie: the rank column is the published file's order, which looks at the average and the best address next.
The rank column is the published file's rank within this place; a skipped number is a business type the file ranks here that this list leaves out to keep any one business family from filling it.
Highest Survivability in Potrero Hill
- #1 Chiropractor Office (Ranked #1): 82.9% average in Potrero Hill. Best-case storefronts: 90.0%. Challenging locations: 66.2%.
- #2 Eye Care Center is ranked #2 for top businesses to open in Potrero Hill: 84.8% chance on average, best at 89.6%, challenging at 71.3%.
- #3 Mental Health Clinic: 78.2% on average across Potrero Hill; best at 89.2%, challenging at 63.6%.
- #4 Opening an Acupuncture Clinic in Potrero Hill shows 78.1% average survivability. Top locations reach 89.2%; lower-end sites show 63.6%.
- #8 Veterinary Clinic (Ranked #8): 74.4% average in Potrero Hill. Best-case storefronts: 87.0%. Challenging locations: 59.4%.
Strong Performers in Potrero Hill
- #9 Clothing Store is ranked #9 for top businesses to open in Potrero Hill: 82.8% chance on average, best at 85.0%, challenging at 72.4%.
- #10 Convenience Store: 80.9% on average across Potrero Hill; best at 85.0%, challenging at 67.4%.
- #11 Opening an International Grocery Store in Potrero Hill shows 78.5% average survivability. Top locations reach 85.0%; lower-end sites show 65.6%.
- #21 Cosmetics Shop (Ranked #21): 75.3% average in Potrero Hill. Best-case storefronts: 84.1%. Challenging locations: 58.9%.
- #22 Pizza Restaurant is ranked #22 for top businesses to open in Potrero Hill: 82.6% chance on average, best at 84.0%, challenging at 76.4%.
Top 3 Compared Nationally
- Chiropractor Office: See how this compares to other cities →
- Eye Care Center: See how this compares to other cities →
- Mental Health Clinic: See how this compares to other cities →
How much money could a business in Potrero Hill make?
Best location vs. average location
Based on StreetSpring's 2026 analysis, selecting one of the best locations for your business in Potrero Hill starts with the Revenue Capture Score, the most important factor in choosing a location: StreetSpring's estimate of the revenue a business can capture at that address.
How StreetSpring calculates location value
- Different business models thrive in different micro-locations.
- Location is one of the few things about a new business you can measure before it opens.
- StreetSpring's Revenue Capture Score, the revenue a business can capture at a specific address, is the factor that matters most when comparing locations.
- StreetSpring generates location-specific predictions tailored to your exact site.
What businesses should open next in Potrero Hill?
The top businesses to open next in Potrero Hill:
- Chiropractor Offices: 82.9% average survival rate, 90.0% at the best address
- Eye Care Centers: 84.8% average survival rate
- Mental Health Clinics: 78.2% average survival rate
Competition and spending patterns shift constantly; StreetSpring's live tool reflects the most current conditions for any specific address. Every prediction draws on a dataset of millions of business openings, closures, and lifecycle events across the U.S. StreetSpring scores 500+ business types: 153 base business types, most of them at 5 price points, which is 569 type-and-price combinations you can choose in the tool. The 10.5% housing vacancy rate in Potrero Hill describes the neighborhood as a whole; survivability still depends heavily on choosing the right address within it. These rankings are a snapshot; StreetSpring regularly recalculates survivability for every location in Potrero Hill, incorporating the latest competitive openings, closures, and spending data: check current locations now.
See the Survivability Score for your new business
Related Articles:
- See the San Francisco Business Survivability Rankings
- See the San Francisco Neighborhood Survivability Rankings
- Explore Chiropractor Office survivability across San Francisco neighborhoods
Frequently Asked Questions
Here are the most common questions about opening a business in Potrero Hill.
What type of business should you rent your Potrero Hill storefront to?
StreetSpring's 2026 model places Chiropractor Offices, Eye Care Centers, and Mental Health Clinics at the top of the survivability rankings for Potrero Hill, making them the safest long-term tenant bets for landlords here.
- Location is one of the few things about a new business you can measure before it opens.
- StreetSpring generates location-specific predictions tailored to your exact site. With StreetSpring, you can rank every potential tenant type by survivability score at your property address before committing to a lease.
Related: See How Landlord Representatives in San Francisco Can Reduce Vacancy & Increase Tenant Longevity
Should you rent your Potrero Hill storefront to a Chiropractor Office?
Yes. Among all business types analyzed for Potrero Hill in 2026, a Chiropractor Office posts the highest survivability ceiling at 90.0% and maintains a reasonable floor of 66.2%, making it the most reliable tenant choice here.
- StreetSpring generates location-specific predictions tailored to your exact site.
What should I consider when opening a business in Potrero Hill?
Start any location decision in Potrero Hill with the Survivability Score: it combines 100+ location factors into one projected two-year chance.
- Revenue Capture Score comes first when comparing locations: it turns local competition and consumer spending into the share of revenue a business can expect to win.
- StreetSpring uses its own proprietary forecasting tools to identify the Revenue Capture Score for each unique business.
- The most current survivability data for Potrero Hill is on StreetSpring, and a free 10-minute trial is enough to check your specific address.
See the best place for your business at StreetSpring.
Real estate professionals and business owners across 24 major metros use StreetSpring to ground their site-selection decisions in data, not guesswork. Aggregated survivability rankings for San Francisco are available in machine-readable format for research and integration purposes.
Full dataset for San Francisco: /resources/data/san-francisco-survivability-scores-2026.csv: includes all business subtypes, all neighborhoods, survivability scores, and tier assignments. Licensed under CC BY 4.0.